Combine Skincare Actives Like a Pro Pt 1

Head over to How to Combine Actives Like a Pro Pt 2 for more. Shopping for a "big 4" product? Checkout community-favorite products here.

Finding that first effective ingredient that makes a visible difference to your skin is a bit like opening pandora’s box. Encouraged, you probably can’t wait to get your hands on all the top of the line actives on the market. But wait! Not every combination works and turns out the relationship can be complicated. So let’s figure out how to combine and handle skincare actives with confidence.

Skincare actives interactions can look a bit like a trashy reality TV relationship map. Let’s start with the Big 4 of Actives: L-ascorbic acid (Vitamin C), AHAs ( glycolic, lactic, and mandelic acid), niacinamide, and retinol

Actives Relationship Map

chemist confessions actives combination

As you can see, in this crude breakdown, it can get confusing even with just 4 actives, so let’s walk through the map together!

1. L-ascorbic acid + Niacinamide - Relationship Status: It’s complicated.

If you do some digging on the interwebs, you’ll soon find many articles telling you to avoid this combination because of the resulting dreaded yellow complex. In a nutshell, this combined niacinamide ascorbate complex is still effective for skincare. However, for optimal efficacy,  we would still exercise caution with products that formulate the 2 together. Reason being, ascorbic acid needs to be in a formula with low pH of 3.5, but intrinsically niacinamide would raise that pH up closer to the 4.5, 5 range without further adjustments. So again, this combo isn’t harmful but there are some steps needed to use these two ingredients together more effectively.

2. Niacnamide + Retinol - Relationship Status: The love is real!

Unfortunately, your reliable neighborhood anti-aging superstar retinol can come with a bit of a mean streak due to its irritation potential. Niacinamide can actually help decrease retinol irritation, and on top of that, it can bolster your skin barrier

3. Retinol + AHAs - Relationship Status: Volatile! Proceed with caution.

These two are both known for effectively increasing cell turnover. We wouldn’t recommend using them together in the same night routine. Um hellooo over-exfoliation! If your skin responds well to both of these, at most we would recommend alternating nights with these two.

4. AHAs + L-ascorbic acid - Relationship Status: Perfect for each other and they know it.

These work around the same pH level and can be layered. While it’s best to leave AHAs for night use, but you can use L-AA both day and night. So if you would like to layer the two, bundle these two for your night routine.

5. L-ascorbic acid + Retinol - Relationship Status: Better as long-distance friends.

Retinol pH needs to be at a higher level (pH~5.5) which doesn’t go well with L-ascorbic’s needs for a pH of 3.5. The best way to have both in your life is to use L-AA during the day and retinol at night. They're just better apart.

Layering Order (Team Water vs Team Oil)

When creating your own layering cocktail, it’s important to consider the layering order. A good rule of thumb to live by is to follow which team (oil or water) the ingredient bats for. Team water ingredients should generally go on before team oil ingredients for the best chance of absorption. As a quick review:

  • Niacinamide: Team water
  • L-ascorbic acid: Team water
  • AHA: Team water (sometimes both)
  • BHA: salicylic acid sorta bats for both teams
  • Retinol: Team oil
  • Vitamin E: Team oil
  • Ceramides: Team oil

Wait Time

The other million dollar question to your layering game is the “20 minute wait time” question. Usually, the reason cited is to avoid different pH levels of the products to “cancel out” each other. In some unrelated studies, we find that if a product affects your skin pH, it takes WAY longer than 20 minutes for skin pH to go back to the usual 5.5 (think more like 2 hours). Real talk, ain’t nobody got time to wait 2 hours to put on the next skin product.

For this reason, we wouldn't worry too much about the different pHs except for the AHA/retinol scenario. Like we said, just alternate if you really are trying to work in both.


Layering and combining skincare actives can be complicated. Finding your core daily routine and building on top of it by carefully experimenting can pay off big time!

For example, Gloria doesn’t respond super well to retinol. So her typical go to is L-AA for day and AHA for night. Once in a while though, she will reintroduce retinol back into her life on an every other day basis, and NOT in conjunction with AHAs.

Meanwhile, Victoria … is a simple soul and likes putting less stuff on her face (*cough...also lazy). While she does use L-AA daily, she'll add three nights of a high dose retinol a week and just follow up with a moisturizer.

Was the actives relationship map helpful? Want us to build it out to include say kojic acid, peptides and more? Check out some of our layering tips in Combine Skincare Actives Like a Pro Pt 2!

Sources and Further Reading

  • Study showing how topical products can affect skin pH 2 hours or more [link]
  • Study demonstrating panthenol and niacinamide’s benefit when using tretinoin [link]


LOVED this article and how it was written. Thank you!

Emz August 17, 2023

Curious about the relationship between Niacinamide and AHAs/BHAs and also where BPO fits into this?

Kt January 12, 2022

Loved this article it gave me a little bit of sense of direction on where to go with my routine But i still need advice. How should i devide my routine in order to incorporate Vitamin C, retinol, and Acids? I would like to use them all but don’t know how to go about doing it? Like when shoul i use what on what days and times etc ? Please help

Edmaris Figueroa August 06, 2021

Hi! just trying to solve a query I have…Can niacinamide and an AHA or a BHA be used together IN THE SAME product? (I thought NO because the PH’s are quite different so would be hard to formulate – but I see products with the combo, so I am confused). Thanks

ari June 29, 2021

Interesting. Can you use niacinamide + salicylic acid + retinol?

Idara April 08, 2021

Thank you for making the science easy to understand, and at the same time fun and interesting to learn! Never take down this article, because it is something one can come back to again and again and again as a helpful reminder to take care with product combinations. Thank you again ladies!

Jessica Fuller March 11, 2021

Thank you for this! What about Matrixyl 3000 with common actives like vitamin c and retinol?

Maya March 11, 2021

This is great! I would definitely love to see this updated with more actives as more evidence is available. I would also love to see this as a chart at some point? (Or maybe it is? I’m with the last commenter and none of the site images are loading)


Bobby March 11, 2021

Thanks for the great content! Is it safe to use niacinamide, then retinol and hyaluronic acid?

John January 19, 2021

Love the info! Please create more content. I am just starting to learn all these and have no routine whatsoever yet. This is really helping. Thank you!

Aarti January 19, 2021

I have a moisturizer that has niacinamide listed as an ingredient. Would it be okay to apply it after applying retinol 0.2%?

Arti Prajapati January 19, 2021

what about retinol and benzoyl peroxide?

Catherine Luchars December 21, 2020

Interesting! Thank you for this informative post! I’m currently trying to figure out where to insert an AHA into my routine, and this helps. I would love to see more achieves added in the future (esp kojic, and tranexamic!). PS. the image at the top isn’t loading, might just be my browser.

Anna November 29, 2020

Leave a comment

All comments are moderated before being published